Read Time: 2 minutes
Frequent aspirin use is linked with lower 卵巢癌 risk in individuals with multiple risk factors, according to a 新的研究 刊登于 Journal of Clinical Oncology.
“Ovarian cancer is the most fatal gynecologic cancer. Most known risk factors of 卵巢癌—such as family history, mutations in the BRCA 1 和 2 genes, 和 endometriosis—can’t be modified,” says Britton Trabert, PhD, MS, investigator in the Cancer Control 和 Population Sciences Program at Huntsman Cancer Institute 和 assistant professor of obstetrics 和 gynecology 在 University of Utah School of Medicine. This new research holds promise because it shows an actionable step people at higher risk of 卵巢癌 can take to reduce their chance of developing the disease.
“每日, 或者几乎每天, aspirin use was associated with a 13% reduction in 卵巢癌 risk 和 we found that aspirin benefitted most subgroups. 重要的是, this research provides further evidence that 卵巢癌 chemoprevention with frequent aspirin use could benefit people in higher-risk subgroups.”
A 2018年的研究 showed daily aspirin use is linked with reduced 卵巢癌 rates. 然而, individual studies have not been able to look at whether aspirin would be beneficial to people at varying risk of disease.
Subgroups were defined by individual factors like endometriosis, 肥胖, a family history of breast or 卵巢癌, 怀孕, oral contraceptive use, 输卵管结扎手术, 和 by number of risk factors: n一个, 一个, 两个或更多.
“We pooled data from 17 studies, nine prospective cohort studies from the 卵巢癌 Cohort Consortium, 和 eight case-control studies from the 卵巢癌 Association Consortium that included more than 8,300 cases. This gave us a more detailed 和 accurate look than if we used published data.”
“Aspirin use has been linked with major adverse events, including internal bleeding 和 stroke. We wanted to evaluate whether aspirin could prevent 卵巢癌 in people at higher risk. Since aspirin helped people who had two or more risk factors, we hope patients 和 clinicians can use this research to have an informed conversation when it comes to potential preventive measures. Individuals should consult their health care providers before beginning new medication in order to most appropriately balance any potential risks with the potential benefits.”
Trabert’s research focuses on identifying strategies for prevention or early detection of ovarian 和 endometrial cancers. Trabert earned a Department of Defense Investigator-Initiated 研究 Award related to her work with aspirin use 和 lower 卵巢癌 rates.
The study was supported by the U.S. Department of Defense Ovarian 癌症研究 Program (W81XWH-19-1-0346).
媒体接触
希瑟·西蒙森
Public Affairs Senior Manager
Huntsman Cancer Institute
801 581-3194
公共.affairs@hci.犹他州.edu
About Huntsman Cancer Institute 在 University of Utah
Huntsman Cancer Institute 在 University of Utah is the National Cancer Institute-designated Comprehensive Cancer Center for Utah, 爱达荷州, 蒙大拿, 内华达, 和怀俄明州. With a legacy of innovative cancer research, groundbreaking discoveries, 和 world-class patient care, we are transforming the way cancer is understood, 预防, 诊断, 治疗, 并存活下来. Huntsman Cancer Institute focuses on delivering the most advanced cancer healing 和 prevention through scientific breakthroughs 和 cutting-edge technology to advance cancer treatments of the future beyond the st和ard of care today. 大发娱乐有超过 300 open clinical trials 和 250 research teams 研究癌症. More genes for inherited cancers have been discovered at Huntsman Cancer Institute than at any other cancer center. Our scientists are world-renowned for underst和ing how cancer begins 和 using that knowledge to develop innovative approaches to treat each patient’s unique disease. Huntsman Cancer Institute was founded by Jon M. 和 Karen Huntsman.